Rheb inhibitor NR1

Names

[ Name ]:
Rheb inhibitor NR1

Biological Activity

[Description]:

Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK; in contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo.

[References]

References 1. Mahoney SJ, et al. Nat Commun. 2018 Feb 7;9(1):548. View Related Products by Target Small GTPase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₁₉BrCl₂N₂O₃S

[ Molecular Weight ]:
578.302

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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