GSK3395879

Names

[ Name ]:
GSK3395879

Biological Activity

[Description]:

GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cardiovascular Disease

[Target]

IC50: 1 nM (hTRPV4)[1]

[References]

[1]. Brnardic EJ, et al. Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4). J Med Chem. 2018 Nov 8;61(21):9738-9755.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₅F₄N₃O₅S

[ Molecular Weight ]:
485.41

Related Compounds

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