Chloromethyl chloroformate
Names
[ CAS No. ]:
22128-62-7
[ Name ]:
Chloromethyl chloroformate
[Synonym ]:
chloromethoxycarbonyl chloride
EINECS 244-793-3
chloromethyl chlorocarbonate
chloroformic acid chloromethyl ester
Carbonochloridic acid, chloromethyl ester
Chloromethyl chloroformate
MFCD00077688
Chlorocarbonate de chlorométhyle
1-chloromethyl chloroformate
chlormethylchlorocarbonat
Chloromethyl carbonochloridate
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
107.9±13.0 °C at 760 mmHg
[ Melting Point ]:
<-20ºC
[ Molecular Formula ]:
C2H2Cl2O2
[ Molecular Weight ]:
128.942
[ Flash Point ]:
25.5±15.2 °C
[ Exact Mass ]:
127.943184
[ PSA ]:
26.30000
[ LogP ]:
1.14
[ Vapour Pressure ]:
26.5±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.432
MSDS
Safety Information
[ Symbol ]:
GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314-H331
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R23;R34
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 2745 6.1/PG 2
[ WGK Germany ]:
3
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
Synthetic Route
Preparation
Articles
Bioorg. Med. Chem. 8(7) , 1719-25, (2000)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, a...
Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.Arch. Pharm. (Weinheim) 340(1) , 32-40, (2007)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carb...
Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.Arch. Pharm. Res. 27(6) , 662-9, (2004)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbon...