Mofebutazone

Names

[ Name ]:
Mofebutazone

[Synonym ]:
monophenylbutazone
4-Butyl-1-phenylpyrazolidin-3,5-dion
mobutazon
4-butyl-1-phenyl-pyrazolidine-3,5-dione
Mofebutazon
monorheumetten
reumatox
MOFEBUTAZONE
2fdbp
arcomonoltablets
mobuzon
monazan
monobutyl

Biological Activity

[Description]:

Mofebutazone, a monophenyl analogue of Phenylbutazone (DPB), is an anti-inflammatory compound. Mofebutazone can be used for research of asthma[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. F.T. Delbeke, et al. Determination of mofebutazone and its 4-hydroxy metabolite in plasma and urine by high-performance liquid chromatography. Journal of Chromatography A. Volume 369, 1986, Pages 440-444

[2]. Khayyal MT,et al. Tolerability of mofebutazone in asthmatic patients. Int J Clin Pharmacol Res. 1995;15(4):145-51.

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Molecular Formula ]:
C₁₃H₁₆N₂O₂

[ Molecular Weight ]:
232.28

[ Exact Mass ]:
232.12100

[ PSA ]:
49.41000

[ LogP ]:
2.26460

[ Index of Refraction ]:
1.541

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ8420000

CHEMICAL NAME :: 3,5-Pyrazolidinedione, 4-butyl-1-phenyl-

CAS REGISTRY NUMBER :: 2210-63-1

BEILSTEIN REFERENCE NO. :: 0213056

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H16-N2-O2

MOLECULAR WEIGHT :: 232.31

WISWESSER LINE NOTATION :: T5VMNV EHJ CR& E4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 39,155,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 848 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,347,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 920 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 37,185,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 233,365,1958

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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