Elomotecan hydrochloride

Names

[ CAS No. ]:
220997-99-9

[ Name ]:
Elomotecan hydrochloride

Biological Activity

[Description]:

Elomotecan (hydrochloride) is a potent inhibitor of topoisomerases I and II. Elomotecan (hydrochloride) is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan (hydrochloride) reduces the proliferation of different tumor cells with higher potency than other anticancer drugs of reference targeting topoisomerases I or II[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase I

Topoisomerase II

[References]

[1]. Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₃Cl₂N₃O₄

[ Molecular Weight ]:
558.50

Related Compounds

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