NPAS3-IN-1

Names

[ Name ]:
NPAS3-IN-1

[Synonym ]:
BI-87G3
2-(5-nitro-thiazol-2-ylsulfanyl)-benzothiazole
5'-Nitro-2'-thiazolyl-2-benzothiazolylsulfiol
JNK INHIBITOR XI

Biological Activity

[Description]:

NPAS3-IN-1 is a potent inhibitor of NPAS3-ARNT heterodimerization and regulates NPAS3 transcription by disrupting the heterodimerization of NPAS3 with ARNT at the cellular level[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Li P, et al. Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT. Bioorg Chem. 2023 Oct;139:106676.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₅N₃O₂S₃

[ Molecular Weight ]:
295.36100

[ Exact Mass ]:
294.95400

[ PSA ]:
153.38000

[ LogP ]:
4.33540

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma.

J. Exp. Med. 212 , 775-92, (2015)

The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmac...

Related Compounds

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