Bamocaftor

Names

[ CAS No. ]:
2204245-48-5

[ Name ]:
Bamocaftor

[Synonym ]:
N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide
3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-

Biological Activity

[Description]:

Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor and Ivacaftor in cystic fibrosis research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Research Areas >> Endocrinology

[In Vitro]

Bamocaftor is a CFTR corrector designed to restore F508del-CFTR protein function[1].

[References]

[1]. Ghelani DP, et al. Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of in Vitro Pharmacology and Clinical Translation.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₃₂F₃N₅O₄S

[ Molecular Weight ]:
591.64

[ Exact Mass ]:
591.212708

[ LogP ]:
5.71

[ Index of Refraction ]:
1.622

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.