2204245-48-5

2204245-48-5 structure

Name: Bamocaftor
Chemical Name: N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide
CAS Number: 2204245-48-5
Molecular Formula: C₂₈H₃₂F₃N₅O₄S
Molecular Weight: 591.64
Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
Create Date: 2021-12-20 19:48:52
Modify Date: 2025-09-11 15:56:04
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor and Ivacaftor in cystic fibrosis research[1].

Name	N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide
Synonyms	N-(Phenylsulfonyl)-6-(3-{2-[1-(trifluoromethyl)cyclopropyl]ethoxy}-1H-pyrazol-1-yl)-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]nicotinamide 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-

Description	Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor and Ivacaftor in cystic fibrosis research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Endocrinology
In Vitro	Bamocaftor is a CFTR corrector designed to restore F508del-CFTR protein function[1].
References	[1]. Ghelani DP, et al. Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of in Vitro Pharmacology and Clinical Translation.