MnTE-2-PyP chloride

MnTE-2-PyP (BMX-010) chloride is a ROS scavenger and potent radioprotector. MnTE-2-PyP also is a manganese porphyrin, protects normal prostate tissue from radiation damage. MnTE-2-PyP can be used for the research of diabetic prostate cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

MnTE-2-PyP (30 μM) protects against hyperglycemiainduced cell death after radiation[1]. MnTE-2-PyP (30 μM) decreases expression of NOX4 and a-SMA, one of the major oxidative enzymes and pro-fibrotic molecules respectively[1]. MnTE-2-PyP (30 μM, 5 days) obstructs NF-kB activity by decreasing DNA binding of the p50-p50 homodimer in the irradiated hyperglycemic environment[1]. MnTE-2-PyP (30 μM) increases NRF2 mediated cytoprotection by increasing NRF2 protein expression and DNA binding[1]. Cell Viability Assay[1] Cell Line: PC-3 cells and LNCaP cells Concentration: 30 μM Incubation Time: Result: Enhanced prostate cancer cell death. RT-PCR[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 5 days Result: Significantly decreased NOX4 mRNA expression. Western Blot Analysis[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 24 h Result: Inhibited NOX4 expression and restored NOX2 expression after radiation. Immunofluorescence[1] Cell Line: Human prostate fibroblast cells Concentration: 30 μM Incubation Time: 5 days Result: Enhanced NRF2 levels.

MnTE2-PyP decreases tumor volume and increases survival in vivo mouse model of prostate cancer[1]. MnTE-2-PyP reduces blood glucose and inhibits pro-fibrotic signaling in a diabetic model[1].

[1]. Arpita Chatterjee, et al. MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses. Redox Biol. 2020 Jul;34:101542.