Zabofloxacin

Names

[ CAS No. ]:
219680-11-2

[ Name ]:
Zabofloxacin

[Synonym ]:
Zabofloxacin
1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(8Z)-8-(methoxyimino)-2,6-diazaspiro[3.4]oct-6-yl]-4-oxo-
UNII-LV66BA6V2G
1-Cyclopropyl-6-fluoro-7-[(8Z)-8-(methoxyimino)-2,6-diazaspiro[3.4]oct-6-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Biological Activity

[Description]:

Zabofloxacin (DW-224a Free base) is a novel fluoronaphthyridone quinolone with a 7-pyrrolidone substituent that is considered a potent antibacterial candidate for clinical trials.Zabofloxacin (DW-224a Free base) has excellent activity against gram-positive pathogens including Steptococcus aureus , Streptococcus pyogenes and S.pneumonia.Zabofloxacin (DW-224a Free base) is considered as an alternative candidate for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Park HS, et al. Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae. Molecules. 2016 Nov 17;21(11). pii: E1562.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
658.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀FN₅O₄

[ Molecular Weight ]:
401.392

[ Flash Point ]:
352.2±34.3 °C

[ Exact Mass ]:
401.149933

[ PSA ]:
109.05000

[ LogP ]:
1.11

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.771

[ Storage condition ]:
-20°C

Related Compounds

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