DSO-5a

Names

[ CAS No. ]:
2195411-63-1

[ Name ]:
DSO-5a

Biological Activity

[Description]:

DSO-5a is a potent, selective, orally active BB3 agonist. DSO-5a is a representative DMAKO-00 derivative compound. DSO-5a upregulates ppar-γ activity through BB3 and activates ERK1/2 phosphorylation. DSO-5a can be used in diabetes-related research[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

PPARγ


[References]

[1]. Wu L, et al. Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus. J Med Chem. 2023 Jun 22;66(12):8011-8029.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24N2O7

[ Molecular Weight ]:
440.45

Related Compounds