DI-404

Names

[ Name ]:
DI-404

Biological Activity

[Description]:

DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.

[References]

1. ZHou HB, Zhou W, Zhou B, Liu L, Chern TR, Chinnaswamy K, Lu J, Bernard D, Yang C, Li S, Wang M, Stuckey JA, Sun Y, Wang S. High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2018 Feb 13. doi: 10.1021/acs.jmedchem.7b01455. [Epub ahead of print] PubMed PMID: 29438612.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₅H₄₅ClN₆O₆S

[ Molecular Weight ]:
713.29

Related Compounds

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