Falcarinol

Names

[ Name ]:
Falcarinol

[Synonym ]:
Carotatoxin
(-)-Falcarinol
(-)-Carotatoxin
1,9-Heptadecadiene-4,6-diyn-3-ol, (3R,9Z)-
(-)-Panaxynol
(−)-(3R)-falcarinol
(3R,9Z)-1,9-Heptadecadiene-4,6-diyn-3-ol
Falcarinol
Panaxynol
(3R,9Z)-Heptadeca-1,9-diene-4,6-diyn-3-ol
Falcarinol

Biological Activity

[Description]:

Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Panaxynol) induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[In Vitro]

Panaxynol inhibits the sphere-forming ability of NSCLC CSCs by inducing apoptosis. Panaxynol suppresses the viability of NSCLC cells with no effects on normal cells[1].

[References]

[1]. Le HT, et al. Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells. Cancer Lett. 2018 Jan 1;412:297-307.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
370.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₄O

[ Molecular Weight ]:
244.372

[ Flash Point ]:
163.4±20.9 °C

[ Exact Mass ]:
244.182709

[ PSA ]:
20.23000

[ LogP ]:
6.96

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.507

Safety Information

[ HS Code ]:
2905290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905290000

[ Summary ]:
2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%