PK68
Names
[ CAS No. ]:
2173556-69-7
[ Name ]:
PK68
Biological Activity
[Description]:
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1].
[Related Catalog]:
[Target]
IC50: ~ 90 nM (RIPK1)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C22H24N4O3S
[ Molecular Weight ]:
424.52