2173556-69-7

2173556-69-7 structure

Name: PK68
Chemical Name: PK68
CAS Number: 2173556-69-7
Molecular Formula: C₂₂H₂₄N₄O₃S
Molecular Weight: 424.52
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2019-08-04 11:52:58
Modify Date: 2024-01-13 18:46:58
PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1].

Name	PK68

Description	PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and with great potential for use in the treatment of inflammatory disorders and cancer metastasis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	IC50: ~ 90 nM (RIPK1)[1]
References	[1]. Hou J, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.

Molecular Formula	C₂₂H₂₄N₄O₃S
Molecular Weight	424.52