TPB15

Names

[ CAS No. ]:
2170347-69-8

[ Name ]:
TPB15

Biological Activity

[Description]:

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo
Signaling Pathways >> Stem Cell/Wnt >> Gli
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

[References]

[1]. Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H9Cl4N5O

[ Molecular Weight ]:
453.11

Related Compounds