SPC-180002

Names

[ Name ]:
SPC-180002

Biological Activity

[Description]:

SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> NF-κB >> Keap1-Nrf2

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT1:1.13 ± 0.3 μM (IC50)

SIRT3:5.41 ± 4.8 μM (IC50)

[References]

[1]. Cho Y, et al. SPC-180002, a SIRT1/3 dual inhibitor, impairs mitochondrial function and redox homeostasis and represents an antitumor activity. Free Radic Biol Med. 2023 Aug 2;208:73-87.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₃NO₄

[ Molecular Weight ]:
317.38

Related Compounds

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