eprodisate

Names

[ Name ]:
eprodisate

[Synonym ]:
propanedisulfonate
Propane-1,3-disulfonate
Eprodisate [INN]
eprodisate
1.3-propanesultone
1,3-propane sulfone
Propane-1,3-disulfonic acid
1,3-propanedisulphonic acid
1,3-Propanedisulfonic acid
1,3-Propanedisulfonicacid
UNII-6QFP76V7S7
P8454_ALDRICH
1,3-Propane disulfonate
MFCD00191483

Biological Activity

[Description]:

Eprodisate is a new compound designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues[1]. Eprodisate slow the progression of AA amyloidosis-related renal disease and has possible applicability to other types of amyloidosis[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Dember LM, et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60.

[2]. Manenti L, et al. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
120-124ºC

[ Molecular Formula ]:
C₃H₈O₆S₂

[ Molecular Weight ]:
204.222

[ Exact Mass ]:
203.976227

[ PSA ]:
125.50000

[ LogP ]:
-3.47

[ Index of Refraction ]:
1.549

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302 + H312 + H332-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Hazard Codes ]:
Xi: Irritant;C: Corrosive;

[ Risk Phrases ]:
36/37/38-34-20/21/22

[ Safety Phrases ]:
S26-S36-S45-S36/37/39-S27

[ RIDADR ]:
3265

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2904100000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2904100000

[ Summary ]:
2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%