Glucocorticoid receptor agonist-2

Names

[ CAS No. ]:
2166378-92-1

[ Name ]:
Glucocorticoid receptor agonist-2

Biological Activity

[Description]:

Glucocorticoid receptor agonist-2 (compound 21) is an Glucocorticoid Receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Glucocorticoid receptor agonist-2 对糖皮质激素受体 (GR) 和孕激素受体 (PR) 结合的 IC50 值分别为 6.6 和 7.3 nM[1]。 Glucocorticoid receptor agonist-2 对糖皮质激素效应元件 (GRE) 报告基因和盐皮质激素受体 (MR) 的 EC50 值分别为 0.2 和 442 nM[1]。 Glucocorticoid receptor agonist-2 对盐皮质激素受体激动活性的 EC50 值为 149 nM[1]。

[References]

[1]. Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H35F2NO7

[ Molecular Weight ]:
607.64

Related Compounds