Cefapirin

Names

[ Name ]:
Cefapirin

[Synonym ]:
(6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefapirin
Cefapirinum
Cefapirina
Cephapirine
7-(2-(4-pyridylthio)acetamido)cephalosporanic acid
Cefapirine
Cefaprin sodium
CEPR
Cefaprin
Cefa
(6R)-3-acetoxymethyl-8-oxo-7t-(2-pyridin-4-ylsulfanyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Biological Activity

[Description]:

Cephapirin (Cefapirin) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Cephapirin (Cefapirin) inhibits Staphylococcus aureus by cephapirin concentrations of 0.09 to 12.5 mug/mL[2]. Cephapirin (Cefapirin) inhibits S. epidermidis, S. viridans, S. pyogenes, and Diplococcus pneumonia isolates by less than 1 mug/mL[2].

[In Vivo]

Cephapirin (Cefapirin) (200 mg; i.m.;cows) is effective for cows infected with S. aureus[3].

[References]

[1]. Bran JL, et al. Clinical and in vitro evaluation of cephapirin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1972 Jan;1(1):35-40.

[2]. Axelrod J, et, al. Cephapirin: in vitro antibacterial spectrum. Appl Microbiol. 1971 Nov;22(5):904-8.

[3]. Roy JP, et, al. Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Can Vet J. 2009 Dec;50(12):1257-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇N₃O₆S₂

[ Molecular Weight ]:
423.46300

[ Exact Mass ]:
423.05600

[ PSA ]:
179.99000

[ LogP ]:
1.25360

[ Vapour Pressure ]:
6.98E-26mmHg at 25°C

Precursor & DownStream

Precursor

DownStream

Related Compounds

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