<Suppliers Price>

I-CBP112 hydrochloride

Names

[ CAS No. ]:
2147701-33-3

[ Name ]:
I-CBP112 hydrochloride

[Synonym ]:
I-CBP112 (hydrochloride)
1-[7-(3,4-Dimethoxyphenyl)-9-{[(3S)-1-methyl-3-piperidinyl]methoxy}-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]-1-propanone hydrochloride (1:1)
1-Propanone, 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-, hydrochloride (1:1)

Biological Activity

[Description]:

I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains (Kds = 142 and 625 nM, respectively). I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Picaud S, et al. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75(23):5106-5119.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H37ClN2O5

[ Molecular Weight ]:
505.046

[ Exact Mass ]:
504.239105

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.