Linsidomine hydrochloride

Names

[ Name ]:
Linsidomine hydrochloride

[Synonym ]:
3-(4-morpholinyl)-5-sydnone imine hydrochloride
[3-(4-Morpholinyl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1)
3-(4-Morpholinyl)sydnone imine hydrochloride Linsidomine hydrochloride SIN-1 hydrochloride
T6N DOTJ A- AT5KNOYJ DUM &&sydnone
SIN-I HYDROCHLORIDE
LINSIDOMINE HCL
3-(4-morpholinyl)-sydnonimine hydrochloride
[3-(Morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1)
MFCD00221615
3-(4-Morpholinyl)sydnone imine hydrochloride
LinsidoMine Chlorhydrate
3-morpholinosydnone imine hydrochloride
1,2,3-Oxadiazolium, 5-amino-3-(4-morpholinyl)-, inner salt, hydrochloride (1:1)
MolsidoMine IMpurity A
SIN-1
SIN-1 CHLORIDE
B-HT 933 dihydrochloride
3-morpholino-sydnonimine hydrochloride
SIN-1 HCL
3-Morpholinosydnonimine hydrochloride
5-Imino-3-(morpholin-4-yl)-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride (1:1)
SIN-1 HYDROCHLORIDE
EINECS 247-207-4
LINSIDOMINE

Biological Activity

[Description]:

SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.

[2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.

Chemical & Physical Properties

[ Melting Point ]:
186 °C

[ Molecular Formula ]:
C₆H₁₁ClN₄O₂

[ Molecular Weight ]:
206.630

[ Exact Mass ]:
206.057053

[ PSA ]:
67.28000

[ Storage condition ]:
-20°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WU7687800

CHEMICAL NAME :: Sydnone imine, 3-morpholino-, monohydrochloride

CAS REGISTRY NUMBER :: 16142-27-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H10-N4-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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