(+)-syringaresinol

Names

[ Name ]:
(+)-syringaresinol

[Synonym ]:
syringaresinol
(+)-(7S,7'S,8R,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignane
4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol)
Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2,6-dimethoxy-
(-) Syringaresinol
(+)-lirioresinol B
(+/-)-syringaresinol
4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenyl]

Biological Activity

[Description]:

(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 329.4 μM (NFAT transcription factor)[1]

[In Vitro]

(+)-Syringaresinol inhibits the growth of P-388 cells, with an ED50 0.41 μg/mL[1].

[References]

[1]. Cai XF, et, al. Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum. Arch Pharm Res. 2004 Jul;27(7):738-41.

[2]. Badawi MM, et, al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). J Pharm Sci. 1983 Nov;72(11):1285-7.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
594.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₆O₈

[ Molecular Weight ]:
418.437

[ Flash Point ]:
313.5±30.1 °C

[ Exact Mass ]:
418.162781

[ PSA ]:
95.84000

[ LogP ]:
0.71

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.578

Related Compounds

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