21453-69-0

21453-69-0 structure

Name: (+)-syringaresinol
Chemical Name: (+)-syringaresinol
CAS Number: 21453-69-0
Molecular Formula: C₂₂H₂₆O₈
Molecular Weight: 418.437
Catalog: Research Areas Cancer
Create Date: 2018-07-19 19:12:46
Modify Date: 2024-01-06 11:01:59
(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia[1][2].

Name	(+)-syringaresinol
Synonyms	syringaresinol (+)-(7S,7'S,8R,8'R)-4,4'-dihydroxy-3,3',5,5'-tetramethoxy-7,9':7',9-diepoxylignane 4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol) Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2,6-dimethoxy- (-) Syringaresinol (+)-lirioresinol B (+/-)-syringaresinol 4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2,6-dimethoxyphenyl]

Description	(+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 329.4 μM (NFAT transcription factor)[1]
In Vitro	(+)-Syringaresinol inhibits the growth of P-388 cells, with an ED50 0.41 μg/mL[1].
References	[1]. Cai XF, et, al. Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum. Arch Pharm Res. 2004 Jul;27(7):738-41. [2]. Badawi MM, et, al. Plant anticancer agents XXVII: Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae). J Pharm Sci. 1983 Nov;72(11):1285-7.