N-(2-HYDROXYPROPYL)METHACRYLAMIDE

Names

[ Name ]:
N-(2-HYDROXYPROPYL)METHACRYLAMIDE

[Synonym ]:
1-methacryloylamino-2-hydroxypropane

Biological Activity

[Description]:

N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) [1][1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vivo]

At 5 mg/kg body weight drug equivalent dose, all N-(2-Hydroxypropyl)methacrylamide copolymer-drug conjugates which contained lysosomally degradable side chains shows significant in vivo antileishmanial activity (>99% inhibition)[1].

[References]

[1]. Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. J Control Release. 2001 Dec 13;77(3):233-43.

[2]. Hao Tang, et al. Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties. Chinese Journal of Polymer Science volume 36, pages1225-1238(2018).

Chemical & Physical Properties

[ Density]:
1.002g/cm3

[ Boiling Point ]:
321.2ºC at 760mmHg

[ Melting Point ]:
70 °C

[ Molecular Formula ]:
C₇H₁₃NO₂

[ Molecular Weight ]:
143.18400

[ Flash Point ]:
148.1ºC

[ Exact Mass ]:
143.09500

[ PSA ]:
49.33000

[ LogP ]:
0.45040

[ Vapour Pressure ]:
2.43E-05mmHg at 25°C

[ Index of Refraction ]:
1.46

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The influence of linker length on the properties of cathepsin S cleavable177Lu-labeled HPMA copolymers for pancreatic cancer imaging

Biomaterials 35(22) , 5760-70, (2014)

N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, ...

Enhanced transcellular penetration and drug delivery by crosslinked polymeric micelles into pancreatic multicellular tumor spheroids.

Biomater. Sci. 3 , 1085-95, (2015)

Many attempts have been made in the application of multicellular tumor spheroids (MCTS) as a 3D tumor model to investigate their biological responses upon introduction of polymeric micelles as nanocar...

Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture.

J. Neurosci. 34(35) , 11781-91, (2014)

The vesicular glutamate transporter (VGLUT) plays an essential role in synaptic transmission by filling vesicles with glutamate. At mammalian synapses, VGLUT expression level determines the amount of ...