HS80

Names

[ Name ]:
HS80

Biological Activity

[Description]:

HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

Research Areas >> Cancer

[Target]

FASN[1]

[In Vitro]

Fasnall, a thiophenopyrimidine selectively targeting FASN through its co-factor binding sites. Fasnall has anti-proliferative activity and induces apoptosis in breast cancer cells[1].

[References]

[1]. Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88.

[Related Small Molecules]

Orlistat | Cerulenin | C75 | FASN-IN-3 | HS79

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₂N₄S

[ Molecular Weight ]:
338.47

Related Compounds

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