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KRP-297

Names

[ CAS No. ]:
213252-19-8

[ Name ]:
KRP-297

[Synonym ]:
[3H]-MK-0767
N-(4-trifluoromethylbenzyl)-5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxybenzamide
[14C]-MK-0767
5-((2,4-Dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide
5-(2,4-dioxothiazolidin-5-ylmethyl)-2-methoxy-N-[4-(trifluoromethyl)benzyl]benzamide
MK 767
MK-0767
5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide
KRP 297

Biological Activity

[Description]:

KRP-297 is a PPARα and PPARγ agonist potentially for the treatment of type 2 diabetes and dyslipidemia. KRP-297 restores reduced lipid oxidation, and inhibits of enhanced lipogenesis and triglyceride accumulation in the liver.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Metabolic Disease

[References]

[1]. Murakami K, Tobe K, Ide T, et al. A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats. Diabetes. 1998;47(12):1841-1847.

[2]. Kochansky CJ, Rippley RK, Yan KX, et al. Absorption, metabolism, and excretion of [14C]MK-0767 (2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in humans. Drug Metab Dispos. 2006;34(9):1457-1461.

Chemical & Physical Properties

[ Density]:
1.395g/cm3

[ Boiling Point ]:
605.4ºC at 760 mmHg

[ Molecular Formula ]:
C20H17F3N2O4S

[ Molecular Weight ]:
438.42000

[ Flash Point ]:
319.9ºC

[ Exact Mass ]:
438.08600

[ PSA ]:
116.78000

[ LogP ]:
4.38880

[ Vapour Pressure ]:
1.32E-14mmHg at 25°C

[ Index of Refraction ]:
1.58

Related Compounds