IDO1-IN-15

Names

[ Name ]:
IDO1-IN-15

Biological Activity

[Description]:

IDO1-IN-15 is a potent IDO1 inhibitor (IC50=127 nM). IDO1-IN-15 has comparable potency against IDO1 enzyme in vitro with Epacadostat[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IDO1:127 nM (IC50)

[In Vitro]

Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1].

[References]

[1]. Wu Y, et al. Discovery of novel IDO1 inhibitors targeting the protein's apo form through scaffold hopping from holo-IDO1 inhibitor. Bioorg Med Chem Lett. 2021;52:128373.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₄BrFN₆O₃

[ Molecular Weight ]:
401.19

Related Compounds

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