C16 PEG2 CERAMIDE

Names

[ Name ]:
C16 PEG2 CERAMIDE

[Synonym ]:
(4E)-3-Hydroxy-2-(palmitoylamino)-4-octadecen-1-yl 2-methoxyethyl succinate
Butanedioic acid, (4E)-3-hydroxy-2-[(1-oxohexadecyl)amino]-4-octadecen-1-yl 2-methoxyethyl ester

Biological Activity

[Description]:

C16 PEG-Ceramide is a polyethylene glycolylated ceramide. C16 PEG-Ceramide can be used for lipid carrier to delivery. C16 PEG-Ceramide induces autophagy. C16 PEG-Ceramide can be used for cancer research[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

C16 PEG-Ceramide (0-118.6μM, 24 hours) has cytotoxicity and promotes autophagy in N2a cells[2]. Cell Cytotoxicity Assay[2]. Cell Line: N2a cells Concentration: 3.7-118.6 μM Incubation Time: 24 hours Result: Inhibits N2a cells activity in a dose-dependent. Western Blot Analysis[2]. Cell Line: N2a cells Concentration: 2.5, 5.0, 10 and 20 μM Incubation Time: 24 hours Result: Increased the LC3-II/LC3-I ratios, reduced the content of WT-Tau and P301L-Tau proteins in the cells.

[References]

[1]. Su X, et, al. Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. Nanomedicine (Lond). 2015;10(13):2033-50.

[2]. Gao J, et, al. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. Int J Nanomedicine. 2020 Sep 11;15:6779-6789.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
753.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₁H₇₇NO₇

[ Molecular Weight ]:
696.053

[ Flash Point ]:
409.6±32.9 °C

[ Exact Mass ]:
695.570007

[ LogP ]:
13.58

[ Vapour Pressure ]:
0.0±5.7 mmHg at 25°C

[ Index of Refraction ]:
1.477

[ Storage condition ]:
2-8°C

Related Compounds

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