Flumorph

Names

[ Name ]:
Flumorph

[Synonym ]:
X5977
(EZ)-4-[3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)acryloyl]morpholine
Flumorph [ISO]
4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propen-1-yl]morpholine
(E)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholin-4-ylprop-2-en-1-one
(2Ξ)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-(morpholin-4-yl)prop-2-en-1-one [50% (E)-isomer, 50% (Z)-isomer]
(EZ)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholinopropenone [50% (E)-isomer, 50% (Z)-isomer]
3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholinoprop-2-en-1-one
Flumorph
4-(3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl)morpholine
(EZ)-4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)acryloyl]morpholine

Biological Activity

[Description]:

Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.IC50 value:Target: Fungicide agentFlumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. In flumorph-treated hyphae, the most characteristic change was the development of periodic swelling ("beaded" morphology) and the disruption of tip growth. Upon removing flumorph, normal tip growth and organized F-actin were observed again [1]. Flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen [2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Others

[References]

[1]. Sheng Zhu S, et al. Flumorph Is a Novel Fungicide That Disrupts Microfilament Organization in Phytophthora melonis. Phytopathology. 2007 May;97(5):643-9.

[2]. Zhang T, et al. Assessment of genotoxic effects of flumorph by the comet assay in mice organs. Hum Exp Toxicol. 2014 Mar;33(3):224-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.208g/cm3

[ Boiling Point ]:
556.3ºC at 760mmHg

[ Melting Point ]:
122-125 °C

[ Molecular Formula ]:
C₂₁H₂₂FNO₄

[ Molecular Weight ]:
371.40200

[ Flash Point ]:
290.3ºC

[ Exact Mass ]:
371.15300

[ PSA ]:
48.00000

[ LogP ]:
3.07130

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.565

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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