R079

Names

[ CAS No. ]:
2115659-62-4

[ Name ]:
R079

Biological Activity

[Description]:

R079 (compound 17) is a selective, orally active Nrf2 activator. R079 increases Nrf2 translocation activity (EC50 = 32.41 μM). R079 can neutralize excess levels of reactive oxygen species through activating Nrf2. R079 has anti-inflammatory properties and can be used in multiple sclerosis research [1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[References]

[1]. Simon J. Shaw, et al. Tuning the Reactivity of Nuclear Factor Erythroid 2 Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy. ACS Medicinal Chemistry Letters . 2023，Article ASAP.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H11N3O3S

[ Molecular Weight ]:
265.29

Related Compounds

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