Sabarubicin

Names

[ Name ]:
Sabarubicin

[Synonym ]:
UNII-XS499WOZ93
Sabarubicin
Sabarubicin [INN]
44D

Biological Activity

[Description]:

Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Arcamone F, Animati F, Berettoni M, et al. Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo. J Natl Cancer Inst. 1997;89(16):1217-1223.

[2]. Mazzini S, Scaglioni L, Animati F, Mondelli R. Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755. Bioorg Med Chem. 2010;18(4):1497-1506.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₇NO₁₃

[ Molecular Weight ]:
643.63500

[ Exact Mass ]:
643.22600

[ PSA ]:
235.53000

[ LogP ]:
0.57400

Related Compounds

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