Dehydrosimvastatin

Names

[ Name ]:
Dehydrosimvastatin

[Synonym ]:
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-8-[2-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]ethyl]-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl ester
anhydrosimvastatin
(1S,3R,7S,8S,8aR)-3,7-Dimethyl-8-{2-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl}-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate
Dehydrosimvastatin
Dehydro Simvastatin
Anhydro-simvastatin
Simvastatin EP Impurity C
Dehydrosimvastatin
Simvastatin Impurity 3

Biological Activity

[Description]:

Anhydrosimvastatin (Impurity C) is an impurity of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. IOANA DRĂGHICI, et al. DEVELOPMENT OF A NEW LC METHOD FOR THE IDENTIFICATION, SEPARATION AND ASSAY OF SIMVASTATIN AND ITS IMPURITIES. FARMACIA, 2013, Vol. 61, 2.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
536.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₆O₄

[ Molecular Weight ]:
400.551

[ Flash Point ]:
265.6±28.5 °C

[ Exact Mass ]:
400.261353

[ PSA ]:
52.60000

[ LogP ]:
5.81

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.529

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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