Sakakin

Names

[ Name ]:
Sakakin

[Synonym ]:
Orcinol glucoside
3-Hydroxy-5-methylphenyl D-glucopyranoside
D-Glucopyranoside, 3-hydroxy-5-methylphenyl

Biological Activity

[Description]:

Orcinol glucoside (OG) is an active constituent isolated from Rhizoma Curculiginis, with antidepressant effects. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Ge JF, et al. Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress. Eur Neuropsychopharmacol. 2014 Jan;24(1):172-80.

[2]. Zhou X, et al. Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway. Drug Des Devel Ther. 2019 Aug 5;13:2703-2713.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
570.6±50.0 °C at 760 mmHg

[ Melting Point ]:
132 °C

[ Molecular Formula ]:
C₁₃H₁₈O₇

[ Molecular Weight ]:
286.278

[ Flash Point ]:
298.9±30.1 °C

[ Exact Mass ]:
286.105255

[ PSA ]:
119.61000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.637

[ Storage condition ]:
?20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport