(R)-Pirtobrutinib

Names

[ Name ]:
(R)-Pirtobrutinib

Biological Activity

[Description]:

(R)-Pirtobrutinib ((R)-LOXO-305) is a less active enantiomer of Pirtobrutinib. Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁F₄N₅O₃

[ Molecular Weight ]:
479.43

Related Compounds

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