2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(17),11E-diene

Names

[ Name ]:
2,5,7,14-Tetraacetoxy-3-benzoyloxy-8,15-dihydroxy-9-nicotinoyloxyjatropha-6(17),11E-diene

[Synonym ]:
(2R,3R,3aS,4R,6R,7S,8S,10Z,12S,13S,13aR)-2,4,6,13-Tetraacetoxy-3-(benzoyloxy)-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-1H-cyclopenta[12]annulen-8-yl nicotinate
3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6R,7S,8S,10Z,12S,13S,13aR)-2,4,6,13-tetrakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester
(2R,3R,3aS,4R,6S,7S,8S,10E,12R,13R,13aR)-2,4,6,13-Tetraacetoxy-3-(benzoyloxy)-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-1H-cyclopenta[12]annulen-8-yl nicotinate
3-Pyridinecarboxylic acid, (2R,3R,3aS,4R,6S,7S,8S,10E,12R,13R,13aR)-2,4,6,13-tetrakis(acetyloxy)-3-(benzoyloxy)-2,3,3a,4,5,6,7,8,9,12,13,13a-dodecahydro-7,13a-dihydroxy-2,9,9,12-tetramethyl-5-methylene-1H-cyclopentacyclododecen-8-yl ester

Biological Activity

[Description]:

Jatrophane 5 is a natural product of Jatropha carcas L. Jatrophane 5 has powerful inhibition of P-gp, higher than R(+)-verapamil (HY-14275) and Tariquidar (HY-10550) in colorectal multi-drug resistant cells (DLD1-TxR)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Jadranin M, et al. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. Phytochemistry. 2013;86:208-217.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
797.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₁H₄₉NO₁₄

[ Molecular Weight ]:
779.826

[ Flash Point ]:
436.0±32.9 °C

[ Exact Mass ]:
779.315308

[ PSA ]:
211.15000

[ LogP ]:
5.46

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.578

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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