Gemcabene calcium
Names
[ CAS No. ]:
209789-08-2
[ Name ]:
Gemcabene calcium
[Synonym ]:
CI-1027
UNII-Z9AM8GST2F
Gemcabene calcium
Biological Activity
[Description]:
Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
[Related Catalog]:
[In Vitro]
Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
[References]
Chemical & Physical Properties
[ Boiling Point ]:
453.6ºC at 760mmHg
[ Molecular Formula ]:
C16H28CaO5
[ Molecular Weight ]:
340.46900
[ Flash Point ]:
156.7ºC
[ Exact Mass ]:
340.15600
[ PSA ]:
89.49000
[ LogP ]:
0.89580
[ Vapour Pressure ]:
1.72E-09mmHg at 25°C