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MLT-747

Names

[ CAS No. ]:
2097853-86-4

[ Name ]:
MLT-747

Biological Activity

[Description]:

MLT-748 is a allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> MALT1
Research Areas >> Inflammation/Immunology

[Target]

IC50: 5 nM (MALT1)[1] Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]


[References]

[1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21Cl2N7O3

[ Molecular Weight ]:
478.33

Related Compounds