para-amino-Blebbistatin

Names

[ CAS No. ]:
2097734-03-5

[ Name ]:
para-amino-Blebbistatin

[Synonym ]:
(3aS)-1-(4-Aminophenyl)-3a-hydroxy-6-methyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
4H-Pyrrolo[2,3-b]quinolin-4-one, 1-(4-aminophenyl)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-, (3aS)-
para-amino-Blebbistatin

Biological Activity

[Description]:

Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Cytoskeleton >> Myosin

Research Areas >> Neurological Disease

[Target]

Myosin II[1]

[References]

[1]. Várkuti BH, et al. A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative. Sci Rep. 2016 May 31;6:26141.

[2]. Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
571.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇N₃O₂

[ Molecular Weight ]:
307.346

[ Flash Point ]:
299.3±32.9 °C

[ Exact Mass ]:
307.132080

[ LogP ]:
0.34

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
2-8°C

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.