CH7057288

Names

[ CAS No. ]:
2095616-82-1

[ Name ]:
CH7057288

Biological Activity

[Description]:

CH7057288 is a potent and selective TRK inhibitor.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

Research Areas >> Cancer

[Target]

TRK

[In Vitro]

CH7057288 induces regression of intracranial tumors and greatly improves event-free survival in an intracranial implantation model mimicking brain metastasis. CH7057288 can be a promising therapeutic agent for TRK fusion-positive cancer. TRK receptor tyrosine kinases are expressed as fusion proteins encoded by various fusion genes across a wide variety of cancer types, including lung and colorectal cancer[1].

[References]

[1]. Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.

[Related Small Molecules]

Entrectinib | LOXO-101 | ANA-12 | LM22B 10 | GW441756 | Repotrectinib | GNF-5837 | Altiratinib | LM22A-4 | Selitrectinib (LOXO-195) | Tyrphostin AG 879 | Belizatinib | Tavilermide | AZ-23 | CE-245677

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₁N₃O₅S

[ Molecular Weight ]:
569.67

[ Storage condition ]:
2-8℃

CH7057288

Names

Biological Activity

Chemical & Physical Properties

Related Compounds