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(R)-eIF4A3-IN-2

Names

[ CAS No. ]:
2095484-82-3

[ Name ]:
(R)-eIF4A3-IN-2

Biological Activity

[Description]:

(R)-eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Eukaryotic initiation factor 4A-3 (eIF4A3) is an Asp-Glu-Ala-Asp (DEAD) box-family adenosine triphosphate (ATP)-dependent RNA helicase[1].

[References]

[1]. Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12(7):1760-1768.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H19Br2ClN4O2

[ Molecular Weight ]:
602.70

Related Compounds