Pegbelfermin

Names

[ CAS No. ]:
2089039-22-3

[ Name ]:
Pegbelfermin

Biological Activity

[Description]:

Pegbelfermin (BMS-986036) is a polyethylene glycol-modified (PEGylated) analogue of human fibroblast growth factor 21 (FGF21). Pegbelfermin can be used for the research of nonalcoholic steatohepatitis (NASH)[1][2].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

FGF21


[In Vivo]

Pegbelfermin 在动物模型中改善 NASH 和纤维化的组织学特征[1]。 Pegbelfermin 显着降低肝脂肪变性和纤维化生物标志物 N 端 III 型胶原蛋白前肽 (PRO-C3)，并改善代谢参数和肝损伤生物标志物[1]。 Pegbelfermin 降低了负责二级胆汁酸合成的基因的表达[1]。

[References]

[1]. Luo Y, et al. Pegbelfermin selectively reduces secondary bile acid concentrations in patients with non-alcoholic steatohepatitis. JHEP Rep. 2021 Nov 12;4(1):100392.  

[2]. Thompson KE, et al. Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys. Toxicol Appl Pharmacol. 2021 Oct 1;428:115673.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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