NS5A-IN-4

Names

[ CAS No. ]:
2088243-03-0

[ Name ]:
NS5A-IN-4

Biological Activity

[Description]:

NS5A-IN-4 (Compound 1.12) is an orally active pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with IC50 values of 1.2, 2296, 4.6, 362, 10.3 and 693 pM against gT1b, gT1a, gT2a, gT3a, gT4a and gT5a[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease

[Target]

IC50: 1.2 pM (gT1b), 4.6 pM (gT2a), 10.3 pM (gT4a), 362 pM (gT3a), 693 pM (gT5a), 2296 pM (gT1a)[1]


[References]

[1]. Ivashchenko AA, et al. Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors. Bioorg Med Chem. 2020 Oct 15;28(20):115716.

Chemical & Physical Properties

[ Molecular Formula ]:
C47H48N8O6

[ Molecular Weight ]:
820.93

Related Compounds