Tz-Thalidomide

Names

[ CAS No. ]:
2087490-42-2

[ Name ]:
Tz-Thalidomide

Biological Activity

[Description]:

Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

46.25 μM (BRD4-1), 62.55 μM (BRD4-2)[1]

[References]

[1]. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₂₉N₇O₆

[ Molecular Weight ]:
571.58

Tz-Thalidomide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds