H-Gly-Gly-AMC hydrochloride salt

Names

[ CAS No. ]:
208645-74-3

[ Name ]:
H-Gly-Gly-AMC hydrochloride salt

[Synonym ]:
gg-mca
H-Gly-Gly-AMC
Glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)glycinamide

Biological Activity

[Description]:

Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Gly-Gly-AMC can be hydrolyzed at very low levels by SW480 and T47D cell extracts[1]. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus[2].

[References]

[1]. Berger Y, et al. Determination of intracellular prolyl/glycyl proteases in intact living human cells and protoporphyrin IX production as a reporter system. Chem Biol. 2005 Aug;12(8):867-72.

[2]. Wildeboer D, et al. Characterization of bacterial proteases with a panel of fluorescent peptide substrates. Anal Biochem. 2009 Jan 15;384(2):321-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₅N₃O₄

[ Molecular Weight ]:
289.28700

[ Exact Mass ]:
289.10600

[ PSA ]:
114.43000

[ LogP ]:
1.27900

Related Compounds

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