L-tert-Leucine

Names

[ CAS No. ]:
20859-02-3

[ Name ]:
L-tert-Leucine

[Synonym ]:
MFCD00002617
L-Tert-Leucine
3-Methyl-L-valine
L-Valine, 3-methyl-
L-tert-leucin
L-2-tert-Butylglycine
Valine, 3-methyl-
(S)-2-Amino-3,3-dimethylbutyric acid
LEUCINE,L
(S)-2-Amino-3,3-dimethylbutanoic acid
3-Methyl valine
EINECS 200-522-0
3-Methylvaline
(S)-2-Amino-4-methylpentanoic acid
L-α-tert-Butylglycine
T-BUTYL GLYCINE
L-tert
H-L-LEU-OH
QVYZX1&1&1 &&L or S Form
L-2-amino-3,3-dimethylbutanoic acid
(2S)-2-amino-3,3-dimethylbutanoic acid
L-Tert-Leu-OH

Biological Activity

[Description]:

(S)-2-amino-3,3-dimethylbutanoic acid is a leucine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
217.7±23.0 °C at 760 mmHg

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C₆H₁₃NO₂

[ Molecular Weight ]:
131.173

[ Flash Point ]:
85.5±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Water Solubility ]:
125.5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OH2850000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.

Org. Lett. 6 , 23-25, (2004)

[reaction: see text] A highly diastereoselective acetate aldol reaction that uses a tert-leucine-derived thiazolidinethione auxiliary and dichlorophenylborane has been developed. The reaction proceeds...

Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acids.

Nature 461(7266) , 968-70, (2009)

Alpha-amino acids are the building blocks of proteins and are widely used as components of medicinally active molecules and chiral catalysts. Efficient chemo-enzymatic methods for the synthesis of ena...

An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.

Org. Lett. 5(20) , 3649-50, (2003)

[reaction: see text] d-tert-Leucine was prepared with an enantiomeric excess of >99% by an enzyme-catalyzed oxidative resolution of the racemic mixture of dl-tert-leucine with use of leucine dehydroge...