CC-90002

Names

[ CAS No. ]:
2085844-54-6

[ Name ]:
CC-90002

Biological Activity

[Description]:

CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

[In Vitro]

CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value[1]. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range[1]. CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines[1].

[In Vivo]

CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models[1].

[References]

[1]. Rama Krishna Narla, et al. The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo.

[2]. Zhongxing Jiang, et al. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021 Oct 30;14(1):180.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds