TP-472

Names

[ CAS No. ]:
2079895-62-6

[ Name ]:
TP-472

[Synonym ]:
3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
3-(6-Acetyl-pyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-benzamide
TP-472
MFCD30536375
Benzamide, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-

Biological Activity

[Description]:

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM; BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay); has a good PK profile and is suitable for in vivo applications.

[References]

References 1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339. View Related Products by Target Bromodomain

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₁₉N₃O₂

[ Molecular Weight ]:
333.384

[ Exact Mass ]:
333.147736

[ LogP ]:
1.25

[ Index of Refraction ]:
1.681

TP-472

Names

Biological Activity

Chemical & Physical Properties

Related Compounds