2079895-62-6
2079895-62-6 structure
- Name: TP-472
- Chemical Name: TP-472
- CAS Number: 2079895-62-6
- Molecular Formula: C20H19N3O2
- Molecular Weight: 333.384
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-11 19:52:01
- Modify Date: 2024-01-23 19:16:12
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TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM; BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay); has a good PK profile and is suitable for in vivo applications.
| Name | TP-472 |
|---|---|
| Synonyms |
3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
3-(6-Acetyl-pyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl-benzamide TP-472 MFCD30536375 Benzamide, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methyl- |
| Description | TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM; BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay); has a good PK profile and is suitable for in vivo applications. |
|---|---|
| References | References 1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339. View Related Products by Target Bromodomain |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H19N3O2 |
| Molecular Weight | 333.384 |
| Exact Mass | 333.147736 |
| LogP | 1.25 |
| Index of Refraction | 1.681 |