RS-601

Names

[ CAS No. ]:
207987-59-5

[ Name ]:
RS-601

[Synonym ]:
4-[4-(5,5,6,6,6-Pentafluoro-1-{[(4-fluorophenyl)sulfonyl]amino}hexyl)phenyl]butanoic acid
4-(4-(5,5,6,6,6-pentafluoro-1-(4-fluorobenzene-sulfonamido)hexyl)phenyl)butyric acid
Benzenebutanoic acid, 4-[5,5,6,6,6-pentafluoro-1-[[(4-fluorophenyl)sulfonyl]amino]hexyl]-

Biological Activity

[Description]:

RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2) dual receptor antagonist, with antiasthmatic activities.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[Target]

LTD4

TXA2 Receptor


[In Vivo]

RS-601 (1-10 mg/kg) clearly inhibits the bronchoconstriction induced by intravenous administration of U-46619 and LTD4 in a dose-dependent fashion in guinea pigs. RS-1452 (10 mg/kg) significantly inhibits U-46619-induced bronchoconstriction, respectively. RS-601 significantly inhibits the late-phase response and LPS-induced AHR at a dose of 10 mg/kg, but does not affect biphasic bronchial responses. RS-601 (3 and 10 mg/kg) also clearly inhibits the AHR[1].

[References]

[1]. Yamada T, et al. Effects of RS-601, a novel leukotriene D(4)/thromboxane A(2) dual receptor antagonist, on asthmatic responses in guinea pigs. Pharmacology. 2003 Sep;69(1):51-8.


[Related Small Molecules]

Dinoprostone | Prostaglandin E1 | MK-571 | E7046 | ONO-AE3-208 | PF 04418948 | Fevipiprant | grapiprant | TG6-10-1 | Taprenepag | Zafirlukast | GW 627368 | MRE-269 | Ramatroban | AH 6809

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
563.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H23F6NO4S

[ Molecular Weight ]:
511.478

[ Flash Point ]:
294.5±32.9 °C

[ Exact Mass ]:
511.125183

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.511

[ Storage condition ]:
2-8℃

Related Compounds